The average train between Mainz, Hauptbahnhof and Hamburg takes 4h 50m and the fastest train takes 4h 26m. There is a train service every few hours from Mainz, Hauptbahnhof to Hamburg. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Mainz, Hauptbahnhof and Hamburg. The earliest departure is at 3:32 AM at night, and the last departure from Mainz, Hauptbahnhof is at 7:32 PM which arrives into Hamburg at 12:40 AM. All services require a transfer, and take on average 4h 50m. The schedules shown below are for the next available departures.

4h 57m • 1 change

4h 57m • 1 change

4h 57m • 1 change

4h 36m • 1 change

4h 58m • 1 change

4h 32m • 1 change

4h 31m • 1 change

4h 31m • 1 change

4h 58m • 1 change

4h 32m • 1 change

4h 31m • 1 change

4h 31m • 1 change
Want to know about travelling from Mainz, Hauptbahnhof to Hamburg? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz, Hauptbahnhof to Hamburg. However, there are services departing from Mainz, Hauptbahnhof station and arriving at Hamburg station via Hamburg Hbf. The journey, including transfers, takes approximately 4h 50m.
Mainz, Hauptbahnhof to Hamburg train services, operated by Deutsche Bahn Regio (DB Regional), depart from Frankfurt station.
Mainz, Hauptbahnhof to Hamburg train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Hamburg Hbf station.
Book your Mainz, Hauptbahnhof to Hamburg train tickets online with Deutsche Bahn Regio (DB Regional), Deutsche Bahn Intercity (DB IC) and 2 other operators.
The distance between Mainz, Hauptbahnhof and Hamburg is 412.3 km. The road distance is 552 km.
Deutsche Bahn Intercity (DB IC) operates a train from Frankfurt to Hamburg Hbf hourly. Tickets cost €90–410 and the journey takes 3h 43m.