The average train between Mainz, Hauptbahnhof and Milan takes 9h 41m and the fastest train takes 7h 31m. The train service runs several times per day from Mainz, Hauptbahnhof to Milan. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Mainz, Hauptbahnhof and Milan. The earliest departure is at 5:40 AM in the morning, and the last departure from Mainz, Hauptbahnhof is at 11:08 PM which arrives into Milan at 11:17 AM. All services require a transfer at Mannheim, Hauptbahnhof and take an average of 9h 41m. The schedules shown below are for the next available departures.



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7h 37m • 3 changes


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7h 37m • 3 changes


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7h 37m • 3 changes


7h 31m • 3 changes


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7h 37m • 3 changes


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7h 37m • 3 changes


7h 31m • 3 changes


8h 4m • 3 changes


8h • 3 changesWant to know about travelling from Mainz, Hauptbahnhof to Milan? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz, Hauptbahnhof to Milan. However, there are services departing from Mainz, Hauptbahnhof station and arriving at Milan station via Mannheim, Hauptbahnhof. The journey, including transfers, takes approximately 9h 41m.
Mainz, Hauptbahnhof to Milan train services, operated by Deutsche Bahn Regio (DB Regional), depart from Mainz, Hauptbahnhof station.
Mainz, Hauptbahnhof to Milan train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Milano Centrale station.
Book your Mainz, Hauptbahnhof to Milan train tickets online with Deutsche Bahn Regio (DB Regional), Deutsche Bahn Intercity (DB IC) and 3 other operators.
The distance between Mainz, Hauptbahnhof and Milan is 509.2 km. The road distance is 652 km.
You can take a train from Mainz, Hauptbahnhof to Milano Centrale via Mannheim, Hauptbahnhof, Basel SBB, and Lugano in around 9h 14m.