The average train between Mainz and Düsseldorf Central Station takes 2h 6m and the fastest train takes 1h 39m. The train service runs several times per day from Mainz to Düsseldorf Central Station. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 3 hours between Mainz and Düsseldorf Central Station. The earliest departure is at 4:04 AM at night, and the last departure from Mainz is at 11:04 PM which arrives into Düsseldorf Central Station at 2:31 AM. All services require a transfer, and take on average 2h 6m. The schedules shown below are for the next available departures.

1h 39m • 1 change

1h 39m • 1 change

1h 39m • 1 change

2h 21m • 1 change

2h 28m • 1 change

1h 40m • 1 change

1h 39m • 1 change

1h 39m • 1 change

2h 28m • 1 change

1h 40m • 1 change

1h 39m • 1 change

1h 39m • 1 change

2h 28m • 1 change

1h 40m • 1 change

1h 39m • 1 change

1h 39m • 1 change

2h 28m • 1 change

1h 40m • 1 change

1h 39m • 1 change

1h 39m • 1 change
Want to know about travelling from Mainz to Düsseldorf Central Station? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Düsseldorf Central Station. However, there are services departing from Mainz station and arriving at Düsseldorf Central Station station via Frankfurt. The journey, including transfers, takes approximately 2h 6m.
Mainz to Düsseldorf Central Station train services, operated by vlexx, depart from Mainz, Römisches Theater station.
Mainz to Düsseldorf Central Station train services, operated by vlexx, arrive at Düsseldorf Hbf station.
Book your Mainz to Düsseldorf Central Station train tickets online with vlexx, Deutsche Bahn Intercity (DB IC) and 3 other operators.
The distance between Mainz and Düsseldorf Central Station is 172.9 km. The road distance is 232 km.
You can take a train from Mainz, Römisches Theater to Düsseldorf Hbf via Frankfurt in around 1h 49m.