The average train between Mainz and Dessau takes 5h 16m and the fastest train takes 4h 45m. There is a train service every few hours from Mainz to Dessau. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Mainz and Dessau. The earliest departure is at 5:05 AM in the morning, and the last departure from Mainz is at 9:14 PM which arrives into Dessau at 5:46 AM. All services require a transfer at Frankfurt and take an average of 5h 16m. The schedules shown below are for the next available departures.


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5h 18m • 2 changesWant to know about travelling from Mainz to Dessau? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Dessau. However, there are services departing from Frankfurt station and arriving at Dessau Hbf station via Leipzig Hbf station. The journey, including transfers, takes approximately 5h 16m.
Mainz to Dessau train services, operated by Deutsche Bahn Intercity (DB IC), depart from Frankfurt station.
Mainz to Dessau train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Dessau Hbf station.
Book your Mainz to Dessau train tickets online with Omio.
The distance between Mainz and Dessau is 346.1 km. The road distance is 414 km.
You can take a train from Mainz, Römisches Theater to Dessau Hbf via Frankfurt and Leipzig Hbf in around 5h 45m.