The average train between Mainz and Frankfurt (Main)Messe takes 50 min and the fastest train takes 42 min. The train runs at least 3 times per hour from Mainz to Frankfurt (Main)Messe. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 20 minutes between Mainz and Frankfurt (Main)Messe. The earliest departure is at 5:05 AM in the morning, and the last departure from Mainz is at 10:35 PM which arrives into Frankfurt (Main)Messe at 11:28 PM. All services require a transfer, and take on average 50 min. The schedules shown below are for the next available departures.

53 min • 1 change

53 min • 1 change

53 min • 1 change

49 min • 1 change
Want to know about travelling from Mainz to Frankfurt (Main)Messe? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Frankfurt (Main)Messe. However, there are services departing from Mainz station and arriving at Frankfurt (Main)Messe station via Frankfurt. The journey, including transfers, takes approximately 50 min.
Mainz to Frankfurt (Main)Messe train services, operated by Deutsche Bahn Regio (DB Regional), depart from Mainz, Römisches Theater station.
Mainz to Frankfurt (Main)Messe train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Frankfurt station.
The distance between Mainz and Frankfurt (Main)Messe is 29.6 km. The road distance is 40 km.
Deutsche Bahn Regio (DB Regional) operates a train from Mainz, Römisches Theater to Frankfurt every 30 minutes. Tickets cost €9–16 and the journey takes 39 min. Two other operators also service this route.