Mainz to Italy Trains

Trip Overview

The average train between Mainz and Italy takes 15h 46m and the fastest train takes 11h 51m. The train service runs several times per day from Mainz to Italy. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

15h 46m
Duration: 1,261 km
Distance: €284
Average price: Every 4 hours
Frequency

Train

best

Take the train from Frankfurt to Basel SBBtrain 43
Take the train from Basel SBB to Luganotrain Ec
Take the train from Lugano to Milano Centraletrain
Take the train from Milano Centrale to Roma Terminitrain

13h 3m

€153–465

Mainz to Italy train times

Trains run every 4 hours between Mainz and Italy. The earliest departure is at 7:05 AM in the morning, and the last departure from Mainz is at 7:14 PM which arrives into Italy at 4:19 PM. All services require a transfer at Frankfurt and take an average of 15h 46m. The schedules shown below are for the next available departures.

Departing Sunday, November 1, 2026

7:05 AM → 7:19 PM
12h 14m • 4 changes
9:14 AM → 9:05 PM
11h 51m • 4 changes
11:14 AM → 11:24 PM
12h 10m • 4 changes
1:14 PM → 9:19 AM
Arrives next day
20h 5m • 4 changes
Show more

Departing Monday, November 2, 2026

7:13 AM → 7:19 PM
12h 6m • 4 changes
9:14 AM → 9:05 PM
11h 51m • 4 changes
11:14 AM → 11:24 PM
12h 10m • 4 changes
1:14 PM → 9:19 AM
Arrives next day
20h 5m • 4 changes
Show more

Departing Tuesday, November 3, 2026

7:13 AM → 7:19 PM
12h 6m • 4 changes
9:14 AM → 9:05 PM
11h 51m • 4 changes
11:14 AM → 11:24 PM
12h 10m • 4 changes
1:14 PM → 9:19 AM
Arrives next day
20h 5m • 4 changes
Show more

Departing Wednesday, November 4, 2026

7:13 AM → 7:19 PM
12h 6m • 4 changes
9:14 AM → 9:05 PM
11h 51m • 4 changes
11:14 AM → 11:24 PM
12h 10m • 4 changes
1:14 PM → 9:19 AM
Arrives next day
20h 5m • 4 changes
Show more

Departing Thursday, November 5, 2026

7:13 AM → 7:19 PM
12h 6m • 4 changes
9:14 AM → 9:05 PM
11h 51m • 4 changes
11:14 AM → 11:24 PM
12h 10m • 4 changes
1:14 PM → 9:19 AM
Arrives next day
20h 5m • 4 changes
Show more

Departing Friday, November 6, 2026

7:13 AM → 7:19 PM
12h 6m • 4 changes
9:14 AM → 9:05 PM
11h 51m • 4 changes
11:14 AM → 11:24 PM
12h 10m • 4 changes
1:14 PM → 9:19 AM
Arrives next day
20h 5m • 4 changes
Show more

Departing Saturday, November 7, 2026

7:05 AM → 7:19 PM
12h 14m • 4 changes
9:14 AM → 9:05 PM
11h 51m • 4 changes
11:14 AM → 11:24 PM
12h 10m • 4 changes

Frequently asked questions

Want to know about travelling from Mainz to Italy? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.