The average train between Mainz and Karlsruhe takes 1h 50m and the fastest train takes 1h 13m. There is an hourly train service from Mainz to Karlsruhe. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Mainz and Karlsruhe. The earliest departure is at 1:43 AM at night, and the last departure from Mainz is at 11:08 PM which arrives into Karlsruhe at 1:48 AM. All services require a transfer, and take on average 1h 50m. The schedules shown below are for the next available departures.

1h 34m • 1 change

1h 59m • 1 change

2h 7m • 1 change

1h 13m • 1 change

3h 39m • 1 change

1h 19m • 1 change

1h 59m • 1 change

2h 7m • 1 change

3h 39m • 1 change

1h 19m • 1 change

1h 59m • 1 change

2h 7m • 1 change
Want to know about travelling from Mainz to Karlsruhe? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Karlsruhe. However, there are services departing from Mainz station and arriving at Karlsruhe station via Mannheim, Hauptbahnhof. The journey, including transfers, takes approximately 1h 50m.
Mainz to Karlsruhe train services, operated by Deutsche Bahn Intercity (DB IC), depart from Mainz, Hauptbahnhof station.
Mainz to Karlsruhe train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Karlsruhe Hauptbahnhof station.
Book your Mainz to Karlsruhe train tickets online with Deutsche Bahn Intercity (DB IC), Deutsche Bahn Regio (DB Regional) and 2 other operators.
The distance between Mainz and Karlsruhe is 108.8 km. The road distance is 130 km.
You can take a train from Mainz, Hauptbahnhof to Karlsruhe Hauptbahnhof via Mannheim, Hauptbahnhof in around 1h 10m.