The average train between Mainz and Leipzig takes 3h 57m and the fastest train takes 3h 55m. There is a train service every few hours from Mainz to Leipzig. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Mainz and Leipzig. The earliest departure is at 5:09 AM in the morning, and the last departure from Mainz is at 9:14 PM which arrives into Leipzig at 1:09 AM. All services require a transfer, and take on average 3h 57m. The schedules shown below are for the next available departures.

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3h 57m • 1 changeWant to know about travelling from Mainz to Leipzig? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Leipzig. However, there are services departing from Mainz station and arriving at Leipzig station via Leipzig Hbf. The journey, including transfers, takes approximately 3h 57m.
Mainz to Leipzig train services, operated by vlexx, depart from Frankfurt station.
Mainz to Leipzig train services, operated by vlexx, arrive at Leipzig Hbf station.
Book your Mainz to Leipzig train tickets online with vlexx, Deutsche Bahn Intercity (DB IC) and Deutsche Bahn Regio (DB Regional).
The distance between Mainz and Leipzig is 325.4 km. The road distance is 409 km.
Deutsche Bahn Intercity (DB IC) operates a train from Frankfurt to Leipzig Hbf hourly. Tickets cost €65–270 and the journey takes 3h 12m.