The average train between Mainz and Lucerne takes 4h 56m and the fastest train takes 4h 51m. The train service runs several times per day from Mainz to Lucerne. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Mainz and Lucerne. The earliest departure is at 7:05 AM in the morning, and the last departure from Mainz is at 7:14 PM which arrives into Lucerne at 12:05 AM. All services require a transfer at Frankfurt and take an average of 4h 56m. The schedules shown below are for the next available departures.


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4h 51m • 2 changesWant to know about travelling from Mainz to Lucerne? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Lucerne. However, there are services departing from Frankfurt station and arriving at Luzern station via Basel SBB station. The journey, including transfers, takes approximately 4h 56m.
Mainz to Lucerne train services, operated by Deutsche Bahn Intercity (DB IC), depart from Frankfurt station.
Mainz to Lucerne train services, operated by Swiss Federal Railways (SBB CFF FFS), arrive at Luzern station.
Book your Mainz to Lucerne train tickets online with Omio.
The distance between Mainz and Lucerne is 326.2 km. The road distance is 421 km.
You can take a train from Mainz, Römisches Theater to Luzern via Frankfurt and Basel SBB in around 5h 29m.