The average train between Mainz and Lugano takes 7h 4m and the fastest train takes 6h 12m. The train service runs several times per day from Mainz to Lugano. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Mainz and Lugano. The earliest departure is at 5:40 AM in the morning, and the last departure from Mainz is at 11:08 PM which arrives into Lugano at 9:58 AM. All services require a transfer at Mannheim, Hauptbahnhof and take an average of 7h 4m. The schedules shown below are for the next available departures.


6h 45m • 2 changes


6h 41m • 2 changes


7h 5m • 2 changes
Arrives next day


10h 50m • 2 changes


6h 18m • 2 changes


6h 12m • 2 changes


6h 45m • 2 changes


6h 41m • 2 changes


6h 18m • 2 changes


6h 12m • 2 changes


6h 45m • 2 changes


6h 41m • 2 changes


6h 18m • 2 changes


6h 12m • 2 changes


6h 45m • 2 changes


6h 41m • 2 changes


6h 18m • 2 changes


6h 12m • 2 changes


6h 45m • 2 changes


6h 41m • 2 changes
Want to know about travelling from Mainz to Lugano? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Lugano. However, there are services departing from Mainz station and arriving at Lugano station via Mannheim, Hauptbahnhof. The journey, including transfers, takes approximately 7h 4m.
Mainz to Lugano train services, operated by Süwex, depart from Mainz, Hauptbahnhof station.
Mainz to Lugano train services, operated by Süwex, arrive at Lugano station.
Book your Mainz to Lugano train tickets online with Süwex, Deutsche Bahn Intercity (DB IC) and 3 other operators.
The distance between Mainz and Lugano is 444.8 km. The road distance is 575 km.
You can take a train from Mainz, Hauptbahnhof to Lugano via Mannheim, Hauptbahnhof and Basel SBB in around 7h 14m.