The average train between Mainz and Milan takes 10h 12m and the fastest train takes 8h 3m. The train service runs several times per day from Mainz to Milan. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Mainz and Milan. The earliest departure is at 7:05 AM in the morning, and the last departure from Mainz is at 7:14 PM which arrives into Milan at 11:17 AM. All services require a transfer at Frankfurt and take an average of 10h 12m. The schedules shown below are for the next available departures.



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8h 3m • 3 changesWant to know about travelling from Mainz to Milan? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Milan. However, there are services departing from Frankfurt station and arriving at Milano Centrale station via Basel SBB station and Lugano station. The journey, including transfers, takes approximately 10h 12m.
Mainz to Milan train services, operated by Deutsche Bahn Intercity (DB IC), depart from Frankfurt station.
Mainz to Milan train services, operated by Swiss Federal Railways (SBB CFF FFS), arrive at Milano Centrale station.
Book your Mainz to Milan train tickets online with Omio.
The distance between Mainz and Milan is 507.2 km. The road distance is 662 km.
You can take a train from Mainz, Römisches Theater to Milano Centrale via Frankfurt, Basel SBB, and Lugano in around 9h 42m.