The average train between Mainz and Milan Cathedral takes 10h 32m and the fastest train takes 8h 12m. The train service runs several times per day from Mainz to Milan Cathedral. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Mainz and Milan Cathedral. The earliest departure is at 7:05 AM in the morning, and the last departure from Mainz is at 9:14 PM which arrives into Milan Cathedral at 9:31 AM. All services require a transfer at Frankfurt and take an average of 10h 32m. The schedules shown below are for the next available departures.




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8h 12m • 4 changes



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8h 20m • 4 changesWant to know about travelling from Mainz to Milan Cathedral? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Milan Cathedral. However, there are services departing from Frankfurt station and arriving at Milano Centrale station via Basel SBB station and Lugano station. The journey, including transfers, takes approximately 10h 32m.
Mainz to Milan Cathedral train services, operated by Deutsche Bahn Intercity (DB IC), depart from Frankfurt station.
Mainz to Milan Cathedral train services, operated by Trenord, arrive at Milano Centrale station.
The distance between Mainz and Milan Cathedral is 507.2 km. The road distance is 664 km.
You can take a train from Mainz, Römisches Theater to Milan Cathedral via Frankfurt, Basel SBB, Lugano, Milano Centrale, Centrale Fs, and Duomo M3 in around 10h.