The average train between Mainz and Osnabrück takes 3h 54m and the fastest train takes 3h 34m. There is a train service every few hours from Mainz to Osnabrück. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Mainz and Osnabrück. The earliest departure is at 4:04 AM at night, and the last departure from Mainz is at 11:14 PM which arrives into Osnabrück at 4:48 AM. All services require a transfer, and take on average 3h 54m. The schedules shown below are for the next available departures.

4h 16m • 1 change

3h 46m • 1 change

3h 46m • 1 change

3h 46m • 1 change

4h 16m • 1 change

3h 46m • 1 change

3h 46m • 1 change

3h 46m • 1 change

4h 17m • 1 change

3h 47m • 1 change

3h 34m • 1 change

3h 47m • 1 change

4h 17m • 1 change

3h 47m • 1 change

3h 34m • 1 change

3h 47m • 1 change
Want to know about travelling from Mainz to Osnabrück? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Osnabrück. However, there are services departing from Mainz station and arriving at Osnabrück station via Osnabrück Hbf. The journey, including transfers, takes approximately 3h 54m.
Mainz to Osnabrück train services, operated by Deutsche Bahn Regio (DB Regional), depart from Frankfurt station.
Mainz to Osnabrück train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Osnabrück Hbf station.
Book your Mainz to Osnabrück train tickets online with Deutsche Bahn Regio (DB Regional), Deutsche Bahn Intercity (DB IC) and 2 other operators.
The distance between Mainz and Osnabrück is 255 km. The road distance is 395 km.
Deutsche Bahn Intercity (DB IC) operates a train from Frankfurt to Osnabrück Hbf hourly. Tickets cost €65–290 and the journey takes 3h 11m.