The average train between Mainz and Wuppertal takes 2h 22m and the fastest train takes 2h 7m. There is a train service every few hours from Mainz to Wuppertal. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Mainz and Wuppertal. The earliest departure is at 5:09 AM in the morning, and the last departure from Mainz is at 8:34 PM which arrives into Wuppertal at 10:54 PM. All services require a transfer at Frankfurt and take an average of 2h 22m. The schedules shown below are for the next available departures.


2h 45m • 2 changes


2h 19m • 2 changes


2h 23m • 2 changes


2h 7m • 2 changes


2h 45m • 2 changes


2h 19m • 2 changes


2h 23m • 2 changes


2h 7m • 2 changes


2h 45m • 2 changes


2h 20m • 2 changes


2h 23m • 2 changes


2h 7m • 2 changes
Want to know about travelling from Mainz to Wuppertal? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Wuppertal. However, there are services departing from Mainz station and arriving at Wuppertal station via Frankfurt. The journey, including transfers, takes approximately 2h 22m.
Mainz to Wuppertal train services, operated by vlexx, depart from Mainz, Römisches Theater station.
Mainz to Wuppertal train services, operated by vlexx, arrive at Wuppertal Hbf station.
Book your Mainz to Wuppertal train tickets online with vlexx, Deutsche Bahn Intercity (DB IC) and 3 other operators.
The distance between Mainz and Wuppertal is 162.4 km. The road distance is 238 km.
You can take a train from Mainz, Römisches Theater to Wuppertal Hbf via Frankfurt, Köln Messe/Deutz Bf, and Koeln Messe/Deutz in around 2h 20m.