The average train between Mainz and Zurich takes 5h 2m and the fastest train takes 4h 46m. The train service runs several times per day from Mainz to Zurich. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Mainz and Zurich. The earliest departure is at 7:05 AM in the morning, and the last departure from Mainz is at 9:14 PM which arrives into Zurich at 5:49 AM. All services require a transfer at Frankfurt and take an average of 5h 2m. The schedules shown below are for the next available departures.


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4h 46m • 2 changesWant to know about travelling from Mainz to Zurich? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Zurich. However, there are services departing from Frankfurt station and arriving at Zürich HB station via Basel SBB station. The journey, including transfers, takes approximately 5h 2m.
Mainz to Zurich train services, operated by Deutsche Bahn Intercity (DB IC), depart from Frankfurt station.
Mainz to Zurich train services, operated by Swiss Federal Railways (SBB CFF FFS), arrive at Zürich HB station.
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The distance between Mainz and Zurich is 291.7 km. The road distance is 370 km.
You can take a train from Mainz, Römisches Theater to Zürich HB via Frankfurt and Basel SBB in around 5h 14m.