The average train between Manchester Airport Station and Southampton takes 4h 42m and the fastest train takes 4h 37m. There is a train service every few hours from Manchester Airport Station to Southampton. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Manchester Airport Station and Southampton. The earliest departure is at 4:48 AM at night, and the last departure from Manchester Airport Station is at 7:04 PM which arrives into Southampton at 11:45 PM. All services require a transfer, and take on average 4h 42m. The schedules shown below are for the next available departures.

4h 55m • 1 change

4h 38m • 1 change

4h 39m • 1 change

4h 39m • 1 change

5h 6m • 1 change

4h 37m • 1 change

4h 43m • 1 change

5h 33m • 1 change

4h 55m • 1 change

4h 39m • 1 change

4h 43m • 1 change

4h 39m • 1 change

4h 55m • 1 change

4h 39m • 1 change

4h 43m • 1 change

4h 39m • 1 change
Want to know about travelling from Manchester Airport Station to Southampton? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Manchester Airport Station to Southampton. However, there are services departing from Manchester Airport Station station and arriving at Southampton station via Southampton Central. The journey, including transfers, takes approximately 4h 42m.
Manchester Airport Station to Southampton train services, operated by TransPennine Express, depart from Manchester Piccadilly station.
Manchester Airport Station to Southampton train services, operated by TransPennine Express, arrive at Southampton Central station.
Book your Manchester Airport Station to Southampton train tickets online with TransPennine Express, Cross Country and Northern Trains Limited.
The distance between Manchester Airport Station and Southampton is 280 km. The road distance is 380 km.
Cross Country operates a train from Manchester Piccadilly to Southampton Central hourly. Tickets cost £120–180 and the journey takes 4h 18m.