The average train between Manchester Piccadilly Station and Middlesex takes 2h 42m and the fastest train takes 2h 23m. The train runs at least 2 times per hour from Manchester Piccadilly Station to Middlesex. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 30 minutes between Manchester Piccadilly Station and Middlesex. The earliest departure is at 5:05 AM in the morning, and the last departure from Manchester Piccadilly Station is at 10:15 PM which arrives into Middlesex at 5:44 AM. All services require a transfer, and take on average 2h 42m. The schedules shown below are for the next available departures.

2h 23m • 1 change

2h 48m • 1 change

2h 43m • 1 change

2h 48m • 1 change

2h 53m • 1 change

2h 32m • 1 change

2h 27m • 1 change

2h 33m • 1 change

3h 23m • 1 change

3h 23m • 1 change

3h 22m • 1 change

2h 53m • 1 change
Want to know about travelling from Manchester Piccadilly Station to Middlesex? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Manchester Piccadilly Station to Middlesex. However, there are services departing from Manchester Piccadilly Station station and arriving at Middlesex station via London Euston. The journey, including transfers, takes approximately 2h 42m.
Manchester Piccadilly Station to Middlesex train services, operated by Avanti West Coast, depart from Manchester Piccadilly station.
Manchester Piccadilly Station to Middlesex train services, operated by Avanti West Coast, arrive at London Euston station.
Book your Manchester Piccadilly Station to Middlesex train tickets online with Avanti West Coast and London Overground.
The distance between Manchester Piccadilly Station and Middlesex is 253.8 km. The road distance is 303 km.
Avanti West Coast operates a train from Manchester Piccadilly to London Euston every 30 minutes. Tickets cost £65–110 and the journey takes 2h 7m.