The average train between Manchester and Annan takes 2h 51m and the fastest train takes 2h 14m. The train service runs several times per day from Manchester to Annan. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 2 hours between Manchester and Annan. The earliest departure is at 4:54 AM at night, and the last departure from Manchester is at 8:21 PM which arrives into Annan at 11:29 PM. All services require a transfer, and take on average 2h 51m. The schedules shown below are for the next available departures.

2h 26m • 1 change

2h 51m • 1 change

2h 53m • 1 change

3h 11m • 1 change

2h 23m • 1 change

2h 51m • 1 change

2h 53m • 1 change

3h 11m • 1 change

2h 23m • 1 change

2h 51m • 1 change

2h 53m • 1 change

3h 11m • 1 change

2h 23m • 1 change

2h 51m • 1 change

2h 53m • 1 change

3h 11m • 1 change
Want to know about travelling from Manchester to Annan? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Manchester to Annan. However, there are services departing from Manchester station and arriving at Annan station via Carlisle. The journey, including transfers, takes approximately 2h 51m.
Manchester to Annan train services, operated by TransPennine Express, depart from Manchester Piccadilly station.
Manchester to Annan train services, operated by TransPennine Express, arrive at Carlisle station.
Book your Manchester to Annan train tickets online with TransPennine Express and ScotRail.
The distance between Manchester and Annan is 180.3 km. The road distance is 222 km.
TransPennine Express operates a train from Manchester Piccadilly to Carlisle hourly. Tickets cost £40–75 and the journey takes 1h 55m.