The average train between Manchester and Carluke takes 3h 57m and the fastest train takes 3h 15m. There is a train service every few hours from Manchester to Carluke. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Manchester and Carluke. The earliest departure is at 6:36 AM in the morning, and the last departure from Manchester is at 11:36 PM which arrives into Carluke at 7:18 AM. All services require a transfer at Motherwell and take an average of 3h 57m. The schedules shown below are for the next available departures.


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3h 56m • 2 changesWant to know about travelling from Manchester to Carluke? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Manchester to Carluke. However, there are services departing from Manchester Piccadilly station and arriving at Motherwell station via Motherwell station. The journey, including transfers, takes approximately 3h 57m.
Manchester to Carluke train services, operated by TransPennine Express, depart from Manchester Piccadilly station.
Manchester to Carluke train services, operated by TransPennine Express, arrive at Motherwell station.
Book your Manchester to Carluke train tickets online with Omio.
The distance between Manchester and Carluke is 270.9 km. The road distance is 319 km.
TransPennine Express operates a train from Manchester Piccadilly to Motherwell every 4 hours. Tickets cost £60–100 and the journey takes 2h 59m.