The average train between Manchester and High Wycombe takes 3h 57m and the fastest train takes 3h 20m. There is a train service every few hours from Manchester to High Wycombe. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Manchester and High Wycombe. The earliest departure is at 5:11 AM in the morning, and the last departure from Manchester is at 8:25 PM which arrives into High Wycombe at 5:58 AM. All services require a transfer, and take on average 3h 57m. The schedules shown below are for the next available departures.

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3h 53m • 1 changeWant to know about travelling from Manchester to High Wycombe? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Manchester to High Wycombe. However, there are services departing from Manchester Piccadilly station and arriving at High Wycombe station via Banbury station. The journey, including transfers, takes approximately 3h 57m.
Manchester to High Wycombe train services, operated by Cross Country, depart from Manchester Piccadilly station.
Manchester to High Wycombe train services, operated by Chiltern Railways, arrive at High Wycombe station.
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The distance between Manchester and High Wycombe is 229.2 km. The road distance is 276 km.
You can take a train from Manchester Piccadilly to High Wycombe via Banbury in around 3h 41m.