The average train between Manchester and Plymouth takes 5h 30m and the fastest train takes 5h 18m. There is a train service every few hours from Manchester to Plymouth. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Manchester and Plymouth. The earliest departure is at 5:11 AM in the morning, and the last departure from Manchester is at 6:25 PM which arrives into Plymouth at 11:43 PM. All services require a transfer, and take on average 5h 30m. The schedules shown below are for the next available departures.

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5h 22m • 1 changeWant to know about travelling from Manchester to Plymouth? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Manchester to Plymouth. However, there are services departing from Manchester station and arriving at Plymouth station via Birmingham New Street. The journey, including transfers, takes approximately 5h 30m.
Manchester to Plymouth train services, operated by Cross Country, depart from Manchester Piccadilly station.
Manchester to Plymouth train services, operated by Cross Country, arrive at Plymouth station.
Book your Manchester to Plymouth train tickets online with Cross Country and Avanti West Coast.
The distance between Manchester and Plymouth is 369.6 km. The road distance is 479 km.
You can take a train from Manchester Piccadilly to Plymouth via Birmingham New Street in around 6h 3m.