The average train between Mannheim and Brussels takes 4h 5m and the fastest train takes 4h 1m. There is a train service every few hours from Mannheim to Brussels. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 2 hours between Mannheim and Brussels. The earliest departure is at 4:01 AM at night, and the last departure from Mannheim is at 7:33 PM which arrives into Brussels at 11:35 PM. All services require a transfer, and take on average 4h 5m. The schedules shown below are for the next available departures.

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4h 1m • 1 changeWant to know about travelling from Mannheim to Brussels? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mannheim to Brussels. However, there are services departing from Mannheim, Hauptbahnhof station and arriving at Bruxelles Midi station via Köln Hbf station. The journey, including transfers, takes approximately 4h 5m.
Mannheim to Brussels train services, operated by Deutsche Bahn Intercity (DB IC), depart from Mannheim, Hauptbahnhof station.
Mannheim to Brussels train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Bruxelles Midi station.
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The distance between Mannheim and Brussels is 330 km. The road distance is 410 km.
You can take a train from Mannheim, Hauptbahnhof to Bruxelles Midi via Köln Hbf in around 4h 12m.