The average train between Mannheim and Enschede takes 5h 12m and the fastest train takes 4h 53m. The train service runs several times per day from Mannheim to Enschede. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 3 hours between Mannheim and Enschede. The earliest departure is at 4:01 AM at night, and the last departure from Mannheim is at 8:34 PM which arrives into Enschede at 6:20 AM. All services require a transfer, and take on average 5h 12m. The schedules shown below are for the next available departures.

4h 53m • 1 change

4h 54m • 1 change

4h 53m • 1 change

4h 54m • 1 change

5h 26m • 1 change

4h 53m • 1 change

4h 54m • 1 change

4h 53m • 1 change

5h 26m • 1 change

4h 53m • 1 change

4h 54m • 1 change

4h 53m • 1 change

5h 26m • 1 change

4h 53m • 1 change

4h 54m • 1 change

4h 53m • 1 change
Want to know about travelling from Mannheim to Enschede? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mannheim to Enschede. However, there are services departing from Mannheim station and arriving at Enschede station via Münster Hauptbahnhof. The journey, including transfers, takes approximately 5h 12m.
Mannheim to Enschede train services, operated by Deutsche Bahn Intercity (DB IC), depart from Mannheim, Hauptbahnhof station.
Mannheim to Enschede train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Enschede station.
Book your Mannheim to Enschede train tickets online with Deutsche Bahn Intercity (DB IC) and Deutsche Bahn Regio (DB Regional).
The distance between Mannheim and Enschede is 322.9 km. The road distance is 456 km.
You can take a train from Mannheim, Hauptbahnhof to Enschede via Münster Hauptbahnhof in around 5h 17m.