The average train between Mannheim and Karlovy Vary takes 6h 45m and the fastest train takes 6h 2m. There is at least one train per day from Mannheim to Karlovy Vary. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run once daily between Mannheim and Karlovy Vary. The earliest departure is at 2:15 AM at night, and the last departure from Mannheim is at 3:29 PM which arrives into Karlovy Vary at 9:38 PM. All services require a transfer at Frankfurt and take an average of 6h 45m. The schedules shown below are for the next available departures.




9h 16m • 4 changes



6h 52m • 4 changes



6h 53m • 4 changes



6h 2m • 4 changesWant to know about travelling from Mannheim to Karlovy Vary? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mannheim to Karlovy Vary. However, there are services departing from Mannheim, Hauptbahnhof station and arriving at Karlovy Vary station via Frankfurt station, Nürnberg Hbf station and Marktredwitz station. The journey, including transfers, takes approximately 6h 45m.
Mannheim to Karlovy Vary train services, operated by Deutsche Bahn Intercity (DB IC), depart from Mannheim, Hauptbahnhof station.
Mannheim to Karlovy Vary train services, operated by České dráhy (ČD), arrive at Karlovy Vary station.
Book your Mannheim to Karlovy Vary train tickets online with Omio.
The distance between Mannheim and Karlovy Vary is 326.3 km. The road distance is 412 km.
You can take a train from Mannheim, Hauptbahnhof to Karlovy Vary via Frankfurt, Nürnberg Hbf, Marktredwitz, and Cheb in around 6h 33m.