The average train between Mannheim and Lugano takes 5h 29m and the fastest train takes 5h 21m. The train service runs several times per day from Mannheim to Lugano. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Mannheim and Lugano. The earliest departure is at 3:31 AM at night, and the last departure from Mannheim is at 6:37 PM which arrives into Lugano at 11:58 PM. All services require a transfer, and take on average 5h 29m. The schedules shown below are for the next available departures.

6h 27m • 1 change

5h 21m • 1 change

5h 21m • 1 change

5h 21m • 1 change

6h 27m • 1 change

5h 21m • 1 change

5h 21m • 1 change

5h 21m • 1 change

6h 27m • 1 change

5h 21m • 1 change

5h 21m • 1 change

5h 21m • 1 change

6h 27m • 1 change

5h 21m • 1 change

5h 21m • 1 change

5h 21m • 1 change
Want to know about travelling from Mannheim to Lugano? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mannheim to Lugano. However, there are services departing from Mannheim station and arriving at Lugano station via Basel SBB. The journey, including transfers, takes approximately 5h 29m.
Mannheim to Lugano train services, operated by Deutsche Bahn Intercity (DB IC), depart from Mannheim, Hauptbahnhof station.
Mannheim to Lugano train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Lugano station.
Book your Mannheim to Lugano train tickets online with Deutsche Bahn Intercity (DB IC), Swiss Federal Railways (SBB CFF FFS) and Nederlandse Spoorwegen (NS).
The distance between Mannheim and Lugano is 388.6 km. The road distance is 506 km.
You can take a train from Mannheim, Hauptbahnhof to Lugano via Basel SBB in around 6h 5m.