The average train between Mannheim and Merseburg takes 4h 33m and the fastest train takes 4h 16m. There is a train service every few hours from Mannheim to Merseburg. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Mannheim and Merseburg. The earliest departure is at 2:15 AM at night, and the last departure from Mannheim is at 11:42 PM which arrives into Merseburg at 6:41 AM. All services require a transfer, and take on average 4h 33m. The schedules shown below are for the next available departures.

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4h 16m • 1 changeWant to know about travelling from Mannheim to Merseburg? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mannheim to Merseburg. However, there are services departing from Mannheim station and arriving at Merseburg station via Erfurt Hbf. The journey, including transfers, takes approximately 4h 33m.
Mannheim to Merseburg train services, operated by Deutsche Bahn Intercity (DB IC), depart from Mannheim, Hauptbahnhof station.
Mannheim to Merseburg train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Merseburg Hbf station.
Book your Mannheim to Merseburg train tickets online with Deutsche Bahn Intercity (DB IC) and Abellio GmbH.
The distance between Mannheim and Merseburg is 324.4 km. The road distance is 427 km.
You can take a train from Mannheim, Hauptbahnhof to Merseburg Hbf via Erfurt Hbf in around 4h 24m.