The average train between Mannheim and Wertheim takes 3h 27m and the fastest train takes 3h 4m. There is a train service every few hours from Mannheim to Wertheim. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 2 hours between Mannheim and Wertheim. The earliest departure is at 2:15 AM at night, and the last departure from Mannheim is at 7:29 PM which arrives into Wertheim at 11:15 PM. All services require a transfer at Frankfurt and take an average of 3h 27m. The schedules shown below are for the next available departures.


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3h 4m • 2 changesWant to know about travelling from Mannheim to Wertheim? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mannheim to Wertheim. However, there are services departing from Mannheim, Hauptbahnhof station and arriving at Wertheim, Bahnhof station via Frankfurt station and Aschaffenburg Hbf station. The journey, including transfers, takes approximately 3h 27m.
Mannheim to Wertheim train services, operated by Deutsche Bahn Intercity (DB IC), depart from Mannheim, Hauptbahnhof station.
Mannheim to Wertheim train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Wertheim, Bahnhof station.
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The distance between Mannheim and Wertheim is 80.8 km. The road distance is 110 km.
You can take a train from Mannheim, Hauptbahnhof to Wertheim, Bahnhof via Frankfurt and Aschaffenburg Hbf in around 3h 29m.