The train between Massachusetts and St. Louis takes 31h 35m. The train runs, on average, 6 times per week from Massachusetts to St. Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 6 times a week between Massachusetts and St. Louis. The earliest departure is at 12:50 PM in the afternoon, and the last departure from Massachusetts is at 12:50 PM which arrives into St. Louis at 7:25 PM. All services require a transfer, and take on average 31h 35m. The schedules shown below are for the next available departures.
Want to know about travelling from Massachusetts to St. Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Massachusetts to St. Louis. However, there are services departing from Massachusetts station and arriving at St. Louis station via Chicago Union Station station. The journey, including transfers, takes approximately 31h 35m.
Massachusetts to St. Louis train services, operated by Amtrak, depart from Boston station.
Massachusetts to St. Louis train services, operated by Amtrak, arrive at St. Louis station.
Book your Massachusetts to St. Louis train tickets online with Amtrak.
The distance between Massachusetts and St. Louis is 1,588 km. The road distance is 2,085 km.
You can take a train from Boston to St. Louis via Chicago Union Station in around 28h 8m.