Mendrisio to Florence Trains

Mendrisio to Florence trains

Travel from

Search accommodation with Expedia

Trip Overview

The average train between Mendrisio and Florence takes 4h 7m and the fastest train takes 3h 17m. There is a train service every few hours from Mendrisio to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 7m
Duration: 363 km
Distance: €63
Average price: Hourly
Frequency

Train

best

Take the train from Mendrisio to Milano Centraletrain Re80
Take the train from Milano Centrale to Firenze S.M.N.train Fr

3h 18m

€50–100

Mendrisio to Florence train times

Trains run hourly between Mendrisio and Florence. The earliest departure is at 6:18 AM in the morning, and the last departure from Mendrisio is at 9:18 PM which arrives into Florence at 7:04 AM. All services require a transfer, and take on average 4h 7m. The schedules shown below are for the next available departures.

Departing Tuesday, November 10, 2026

6:18 AM → 10:04 AM
3h 46m • 1 change
7:18 AM → 11:04 AM
3h 46m • 1 change
8:18 AM → 12:04 PM
3h 46m • 1 change
9:18 AM → 12:35 PM
3h 17m • 1 change
Show more

Departing Wednesday, November 11, 2026

6:18 AM → 10:04 AM
3h 46m • 1 change
7:18 AM → 11:04 AM
3h 46m • 1 change
8:18 AM → 12:04 PM
3h 46m • 1 change
9:18 AM → 12:35 PM
3h 17m • 1 change
Show more

Departing Thursday, November 12, 2026

6:18 AM → 10:04 AM
3h 46m • 1 change
7:18 AM → 11:04 AM
3h 46m • 1 change
8:18 AM → 12:04 PM
3h 46m • 1 change
9:18 AM → 12:35 PM
3h 17m • 1 change
Show more

Departing Friday, November 13, 2026

6:18 AM → 10:04 AM
3h 46m • 1 change
7:18 AM → 11:04 AM
3h 46m • 1 change
8:18 AM → 12:04 PM
3h 46m • 1 change
9:18 AM → 12:35 PM
3h 17m • 1 change
Show more

Departing Saturday, November 14, 2026

6:18 AM → 10:04 AM
3h 46m • 1 change
7:18 AM → 11:04 AM
3h 46m • 1 change
8:18 AM → 12:04 PM
3h 46m • 1 change
9:18 AM → 12:35 PM
3h 17m • 1 change
Show more

Departing Sunday, November 15, 2026

6:18 AM → 10:04 AM
3h 46m • 1 change
7:18 AM → 11:04 AM
3h 46m • 1 change
8:18 AM → 12:04 PM
3h 46m • 1 change
9:18 AM → 12:35 PM
3h 17m • 1 change
Show more

Departing Monday, November 16, 2026

6:18 AM → 10:04 AM
3h 46m • 1 change
7:18 AM → 11:04 AM
3h 46m • 1 change
8:18 AM → 12:04 PM
3h 46m • 1 change
9:18 AM → 12:35 PM
3h 17m • 1 change
Show more

Frequently asked questions

Want to know about travelling from Mendrisio to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.