The average train between Mendrisio and Sesto San Giovanni takes 1h and the fastest train takes 58 min. There is a train service every few hours from Mendrisio to Sesto San Giovanni. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Mendrisio and Sesto San Giovanni. The earliest departure is at 6:18 AM in the morning, and the last departure from Mendrisio is at 9:32 PM which arrives into Sesto San Giovanni at 10:51 PM. All services require a transfer, and take on average 1h. The schedules shown below are for the next available departures.

58 min • 1 change

58 min • 1 change

1h 5m • 1 change

58 min • 1 change

58 min • 1 change

58 min • 1 change

1h 5m • 1 change

58 min • 1 change

58 min • 1 change

58 min • 1 change

1h 5m • 1 change

58 min • 1 change
Want to know about travelling from Mendrisio to Sesto San Giovanni? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mendrisio to Sesto San Giovanni. However, there are services departing from Mendrisio station and arriving at Sesto San Giovanni station via Monza. The journey, including transfers, takes approximately 1h.
Mendrisio to Sesto San Giovanni train services, operated by Trenord, depart from Mendrisio station.
Mendrisio to Sesto San Giovanni train services, operated by Trenord, arrive at Monza station.
The distance between Mendrisio and Sesto San Giovanni is 41.9 km. The road distance is 51 km.
Trenord operates a train from Mendrisio to Monza hourly. Tickets cost €4–6 and the journey takes 48 min.