The average train between Mesagne and Milan takes 12h 58m and the fastest train takes 10h 7m. The train service runs several times per day from Mesagne to Milan. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Mesagne and Milan. The earliest departure is at 6:18 AM in the morning, and the last departure from Mesagne is at 7:44 PM which arrives into Milan at 3:10 PM. All services require a transfer, and take on average 12h 58m. The schedules shown below are for the next available departures.

11h 27m • 1 change

10h 52m • 1 change

10h 7m • 1 change
Arrives next day

19h 26m • 1 change

11h 27m • 1 change

10h 52m • 1 change

10h 7m • 1 change
Arrives next day

19h 26m • 1 change

11h 27m • 1 change

10h 52m • 1 change

10h 7m • 1 change
Arrives next day

19h 26m • 1 change
Want to know about travelling from Mesagne to Milan? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mesagne to Milan. However, there are services departing from Mesagne station and arriving at Milan station via Milano Centrale. The journey, including transfers, takes approximately 12h 58m.
Mesagne to Milan train services, operated by Trenitalia, depart from Brindisi station.
Mesagne to Milan train services, operated by Trenitalia, arrive at Milano Centrale station.
Book your Mesagne to Milan train tickets online with Trenitalia, Trenitalia Intercity and Trenitalia Frecce.
The distance between Mesagne and Milan is 887.2 km. The road distance is 983 km.
Trenitalia Frecce operates a train from Brindisi to Milano Centrale every 4 hours. Tickets cost €140–290 and the journey takes 8h 41m. Trenitalia Intercity also services this route every 4 hours.