The average train between Mesagne and Rome takes 9h 14m and the fastest train takes 6h 17m. The train service runs several times per day from Mesagne to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Mesagne and Rome. The earliest departure is at 6:58 AM in the morning, and the last departure from Mesagne is at 7:44 PM which arrives into Rome at 12:05 PM. All services require a transfer, and take on average 9h 14m. The schedules shown below are for the next available departures.

6h 17m • 1 change

7h 27m • 1 change

6h 51m • 1 change
Arrives next day

16h 21m • 1 change

6h 17m • 1 change

7h 27m • 1 change

6h 51m • 1 change
Arrives next day

16h 21m • 1 change

6h 17m • 1 change

7h 27m • 1 change

6h 51m • 1 change
Arrives next day

16h 21m • 1 change
Want to know about travelling from Mesagne to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mesagne to Rome. However, there are services departing from Mesagne station and arriving at Rome station via Roma Termini. The journey, including transfers, takes approximately 9h 14m.
Mesagne to Rome train services, operated by Trenitalia, depart from Brindisi station.
Mesagne to Rome train services, operated by Trenitalia, arrive at Roma Termini station.
Book your Mesagne to Rome train tickets online with Trenitalia and Trenitalia Frecce.
The distance between Mesagne and Rome is 468.1 km. The road distance is 603 km.
Trenitalia Frecce operates a train from Brindisi to Roma Termini every 3 hours. Tickets cost €85–180 and the journey takes 5h 42m.