The average train between Mestre and Pisa takes 3h 30m and the fastest train takes 3h 11m. There is a train service every few hours from Mestre to Pisa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Mestre and Pisa. The earliest departure is at 5:00 AM in the morning, and the last departure from Mestre is at 7:38 PM which arrives into Pisa at 11:22 PM. All services require a transfer, and take on average 3h 30m. The schedules shown below are for the next available departures.

3h 13m • 1 change
3h 26m • 1 change
3h 13m • 1 change
3h 26m • 1 change
3h 26m • 1 change
3h 26m • 1 change
3h 26m • 1 change
3h 11m • 1 change
3h 26m • 1 change
3h 26m • 1 change
3h 26m • 1 change
3h 11m • 1 change
3h 26m • 1 change
3h 26m • 1 change
3h 26m • 1 change
3h 11m • 1 change
4h 4m • 1 change
4h • 1 change
3h 55m • 1 change
3h 54m • 1 change
4h 4m • 1 change
4h 2m • 1 change
4h 28m • 1 change
3h 46m • 1 change
3h 26m • 1 change
3h 26m • 1 change
3h 26m • 1 change
3h 11m • 1 changeWant to know about travelling from Mestre to Pisa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mestre to Pisa. However, there are services departing from Venezia Mestre station and arriving at Pisa Centrale station via Firenze S.M.N. station. The journey, including transfers, takes approximately 3h 30m.
Mestre to Pisa train services, operated by Trenitalia Frecce, depart from Venezia Mestre station.
Mestre to Pisa train services, operated by Trenitalia, arrive at Pisa Centrale station.
Book your Mestre to Pisa train tickets online with Omio.
The distance between Mestre and Pisa is 246.1 km. The road distance is 317 km.
You can take a train from Venezia Mestre to Pisa Centrale via Firenze S.M.N. in around 3h 35m.