Mestre to Siena Trains

Mestre to Siena trains

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Trip Overview

The average train between Mestre and Siena takes 4h 37m and the fastest train takes 3h 58m. There is a train service every few hours from Mestre to Siena. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 37m
Duration: 336 km
Distance: €52
Average price: Hourly
Frequency

Train

best

Take the train from Venezia Mestre to Firenze S.M.N.train Fr
Take the train from Firenze S.M.N. to Sienatrain Re

4h 21m

€40–72

Mestre to Siena train times

Trains run hourly between Mestre and Siena. The earliest departure is at 5:00 AM in the morning, and the last departure from Mestre is at 7:38 PM which arrives into Siena at 7:55 AM. All services require a transfer, and take on average 4h 37m. The schedules shown below are for the next available departures.

Departing Sunday, November 8, 2026

5:00 AM → 9:38 AM
4h 38m • 1 change
8:05 AM → 12:38 PM
4h 33m • 1 change
8:47 AM → 1:40 PM
4h 53m • 1 change
11:31 AM → 6:40 PM
7h 9m • 1 change
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Departing Monday, November 9, 2026

5:38 AM → 9:38 AM
4h • 1 change
6:38 AM → 10:40 AM
4h 2m • 1 change
7:38 AM → 11:40 AM
4h 2m • 1 change
8:40 AM → 12:38 PM
3h 58m • 1 change
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Departing Tuesday, November 10, 2026

5:38 AM → 9:38 AM
4h • 1 change
6:38 AM → 10:40 AM
4h 2m • 1 change
7:38 AM → 11:40 AM
4h 2m • 1 change
8:40 AM → 12:38 PM
3h 58m • 1 change
Show more

Departing Wednesday, November 11, 2026

5:38 AM → 9:38 AM
4h • 1 change
6:38 AM → 10:40 AM
4h 2m • 1 change
7:38 AM → 11:40 AM
4h 2m • 1 change
8:40 AM → 12:38 PM
3h 58m • 1 change
Show more

Departing Thursday, November 12, 2026

5:38 AM → 9:38 AM
4h • 1 change
6:38 AM → 10:40 AM
4h 2m • 1 change
7:38 AM → 11:40 AM
4h 2m • 1 change
8:40 AM → 12:38 PM
3h 58m • 1 change
Show more

Departing Friday, November 13, 2026

5:38 AM → 9:38 AM
4h • 1 change
6:38 AM → 10:40 AM
4h 2m • 1 change
7:38 AM → 11:40 AM
4h 2m • 1 change
8:40 AM → 12:38 PM
3h 58m • 1 change
Show more

Departing Saturday, November 14, 2026

5:38 AM → 9:38 AM
4h • 1 change
6:38 AM → 10:40 AM
4h 2m • 1 change
7:38 AM → 11:40 AM
4h 2m • 1 change
8:40 AM → 12:38 PM
3h 58m • 1 change
Show more

Frequently asked questions

Want to know about travelling from Mestre to Siena? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.