Mestre to Siena Trains

Mestre to Siena trains

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Trip Overview

The average train between Mestre and Siena takes 4h 34m and the fastest train takes 3h 58m. There is a train service every few hours from Mestre to Siena. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 34m
Duration: 336 km
Distance: €53
Average price: Hourly
Frequency

Train

best

Take the train from Venezia Mestre to Firenze S.M.N.train Fr
Take the train from Firenze S.M.N. to Sienatrain Re

3h 56m

€40–72

Mestre to Siena train times

Trains run hourly between Mestre and Siena. The earliest departure is at 5:38 AM in the morning, and the last departure from Mestre is at 7:38 PM which arrives into Siena at 7:55 AM. All services require a transfer, and take on average 4h 34m. The schedules shown below are for the next available departures.

Departing Monday, October 19, 2026

5:38 AM → 9:38 AM
4h • 1 change
6:38 AM → 10:40 AM
4h 2m • 1 change
7:38 AM → 11:40 AM
4h 2m • 1 change
8:40 AM → 12:38 PM
3h 58m • 1 change
Show more

Departing Tuesday, October 20, 2026

5:38 AM → 9:38 AM
4h • 1 change
6:38 AM → 10:40 AM
4h 2m • 1 change
7:38 AM → 11:40 AM
4h 2m • 1 change
8:40 AM → 12:38 PM
3h 58m • 1 change
Show more

Departing Wednesday, October 21, 2026

5:38 AM → 9:38 AM
4h • 1 change
6:38 AM → 10:40 AM
4h 2m • 1 change
7:38 AM → 11:40 AM
4h 2m • 1 change
8:40 AM → 12:38 PM
3h 58m • 1 change
Show more

Departing Thursday, October 22, 2026

5:38 AM → 9:38 AM
4h • 1 change
6:38 AM → 10:40 AM
4h 2m • 1 change
7:38 AM → 11:40 AM
4h 2m • 1 change
8:40 AM → 12:38 PM
3h 58m • 1 change
Show more

Frequently asked questions

Want to know about travelling from Mestre to Siena? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.