The average train between Milan Cathedral and Roma Termini takes 3h 50m and the fastest train takes 3h 29m. There is a train service every few hours from Milan Cathedral to Roma Termini. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Milan Cathedral and Roma Termini. The earliest departure is at 5:20 AM in the morning, and the last departure from Milan Cathedral is at 7:10 PM which arrives into Roma Termini at 11:24 PM. All services require a transfer at via grossi and take an average of 3h 50m. The schedules shown below are for the next available departures.

4h 8m • 1 change
3h 46m • 1 change
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3h 29m • 1 change
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3h 42m • 1 change
3h 29m • 1 change
3h 59m • 1 change
3h 45m • 1 change
3h 42m • 1 change
3h 29m • 1 change
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3h 29m • 1 change
3h 59m • 1 change
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3h 33m • 1 changeWant to know about travelling from Milan Cathedral to Roma Termini? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Milan Cathedral to Roma Termini. However, there are services departing from Milano Centrale station and arriving at Roma Termini station via Roma Termini station. The journey, including transfers, takes approximately 3h 50m.
Milan Cathedral to Roma Termini train services, operated by ItaloTreno, depart from Milano Centrale station.
Milan Cathedral to Roma Termini train services, operated by ItaloTreno, arrive at Roma Termini station.
The distance between Milan Cathedral and Roma Termini is 477.2 km. The road distance is 569 km.
ItaloTreno operates a train from Milano Centrale to Roma Termini every 30 minutes. Tickets cost €65–120 and the journey takes 3h 5m.