The average train between Milan Cathedral and Roma Termini takes 5h 5m and the fastest train takes 4h 36m. There is a train service every few hours from Milan Cathedral to Roma Termini. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Milan Cathedral and Roma Termini. The earliest departure is at 12:37 AM at night, and the last departure from Milan Cathedral is at 7:33 PM which arrives into Roma Termini at 12:24 AM. All services require a transfer at via larga and take an average of 5h 5m. The schedules shown below are for the next available departures.

8h 48m • 1 change

4h 41m • 1 change

4h 36m • 1 change

4h 53m • 1 change

8h 48m • 1 change

4h 41m • 1 change

4h 36m • 1 change

4h 53m • 1 change

8h 48m • 1 change

4h 41m • 1 change

4h 36m • 1 change

4h 53m • 1 change
Want to know about travelling from Milan Cathedral to Roma Termini? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Milan Cathedral to Roma Termini. However, there are services departing from Milan Cathedral station and arriving at Roma Termini station via Roma Termini. The journey, including transfers, takes approximately 5h 5m.
Milan Cathedral to Roma Termini train services, operated by ATM, depart from Milano Centrale station.
Milan Cathedral to Roma Termini train services, operated by ATM, arrive at Roma Termini station.
The distance between Milan Cathedral and Roma Termini is 477.2 km. The road distance is 586 km.
ItaloTreno operates a train from Milano Centrale to Roma Termini every 30 minutes. Tickets cost €70–150 and the journey takes 3h 5m.