The average train between Milan Cathedral and Rome takes 4h 2m and the fastest train takes 3h 22m. There is a train service every few hours from Milan Cathedral to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Milan Cathedral and Rome. The earliest departure is at 12:33 AM at night, and the last departure from Milan Cathedral is at 7:20 PM which arrives into Rome at 11:24 PM. All services require a transfer at Duomo M1 and take an average of 4h 2m. The schedules shown below are for the next available departures.

8h 45m • 1 change

3h 29m • 1 change

3h 29m • 1 change

4h 3m • 1 change

8h 45m • 1 change

3h 29m • 1 change

3h 29m • 1 change

4h 3m • 1 change

8h 45m • 1 change

3h 29m • 1 change

3h 29m • 1 change

4h 3m • 1 change
Want to know about travelling from Milan Cathedral to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Milan Cathedral to Rome. However, there are services departing from Milan Cathedral station and arriving at Rome station via Roma Termini. The journey, including transfers, takes approximately 4h 2m.
Milan Cathedral to Rome train services, operated by ATM, depart from Milano Rogoredo station.
Milan Cathedral to Rome train services, operated by ATM, arrive at Roma Termini station.
The distance between Milan Cathedral and Rome is 477.2 km. The road distance is 582 km.
ItaloTreno operates a train from Milano Rogoredo to Roma Termini every 30 minutes. Tickets cost €70–150 and the journey takes 2h 55m.