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Milan Cathedral to Rome trains

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Trip Overview

The average train between Milan Cathedral and Rome takes 4h 21m and the fastest train takes 3h 23m. The train service runs several times per day from Milan Cathedral to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 21m
Duration
582 km
Distance
€82
Average price
Twice daily
Frequency

Milan Cathedral to Rome train times

Trains run twice daily between Milan Cathedral and Rome. The earliest departure is at 12:13 AM at night, and the last departure from Milan Cathedral is at 7:20 PM which arrives into Rome at 11:24 PM. All services require a transfer at Duomo M1 and take an average of 4h 21m. The schedules shown below are for the next available departures.

Departing Monday, October 19, 2026

  •  → 

    ATMItaloTreno4h 5m • 1 change
  •  → 

    ATMItaloTreno3h 33m • 1 change
  •  → 

    ATMItaloTreno4h 1m • 1 change
  •  → 

    ATMItaloTreno3h 27m • 1 change
  • Show more

Departing Tuesday, October 20, 2026

  •  → 

    ATMItaloTreno9h 5m • 1 change

Frequently asked questions

Want to know about travelling from Milan Cathedral to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Milan Cathedral to Rome.ExpandLaunch map view
  • Distance: 582.1 km
  • Duration: 4h 21m

What companies run services between Milan Cathedral, Lombardy, Italy and Rome, Italy?

ItaloTreno operates a train from Milano Rogoredo to Roma Termini every 30 minutes. Tickets cost €65–110 and the journey takes 2h 55m.

Operators