The average train between Milan and Ascoli Piceno takes 6h 49m and the fastest train takes 5h 5m. The train service runs several times per day from Milan to Ascoli Piceno. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Milan and Ascoli Piceno. The earliest departure is at 5:25 AM in the morning, and the last departure from Milan is at 7:50 PM which arrives into Ascoli Piceno at 7:53 AM. All services require a transfer, and take on average 6h 49m. The schedules shown below are for the next available departures.

6h 55m • 1 change
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7h 17m • 1 change
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5h 10m • 1 changeWant to know about travelling from Milan to Ascoli Piceno? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Milan to Ascoli Piceno. However, there are services departing from Milano Centrale station and arriving at Ascoli Piceno station via Ancona station. The journey, including transfers, takes approximately 6h 49m.
Milan to Ascoli Piceno train services, operated by Trenitalia Frecce, depart from Milano Centrale station.
Milan to Ascoli Piceno train services, operated by Trenitalia, arrive at Ascoli Piceno station.
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The distance between Milan and Ascoli Piceno is 454.4 km. The road distance is 539 km.
You can take a train from Milano Centrale to Ascoli Piceno via Ancona in around 5h 56m.