The average train between Milan and Isernia takes 7h 9m and the fastest train takes 5h 42m. The train service runs several times per day from Milan to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Milan and Isernia. The earliest departure is at 9:35 AM in the morning, and the last departure from Milan is at 8:35 PM which arrives into Isernia at 8:27 AM. All services require a transfer, and take on average 7h 9m. The schedules shown below are for the next available departures.
Want to know about travelling from Milan to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Milan to Isernia. However, there are services departing from Milan station and arriving at Isernia station via Roma Termini. The journey, including transfers, takes approximately 7h 9m.
Milan to Isernia train services, operated by Trenitalia Frecce, depart from Milano Centrale station.
Milan to Isernia train services, operated by Trenitalia Frecce, arrive at Isernia station.
Book your Milan to Isernia train tickets online with Trenitalia Frecce and Trenitalia.
The distance between Milan and Isernia is 591.7 km. The road distance is 747 km.
You can take a train from Milano Centrale to Isernia via Roma Termini in around 6h 12m.
