The average train between Milan and Neu-Isenburg takes 9h 21m and the fastest train takes 8h 21m. The train service runs several times per day from Milan to Neu-Isenburg. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run twice daily between Milan and Neu-Isenburg. The earliest departure is at 7:10 AM in the morning, and the last departure from Milan is at 6:05 PM which arrives into Neu-Isenburg at 4:41 AM. All services require a transfer at Frankfurt(Main)Hbf and take an average of 9h 21m. The schedules shown below are for the next available departures.


8h 21m • 2 changes


8h 21m • 2 changes
Arrives next day


10h 36m • 2 changes


8h 21m • 2 changes


8h 21m • 2 changes
Arrives next day


10h 36m • 2 changes


8h 21m • 2 changes


8h 21m • 2 changes
Arrives next day


10h 36m • 2 changes
Want to know about travelling from Milan to Neu-Isenburg? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Milan to Neu-Isenburg. However, there are services departing from Milan station and arriving at Neu-Isenburg station via Frankfurt(Main)Hbf. The journey, including transfers, takes approximately 9h 21m.
Milan to Neu-Isenburg train services, operated by Trenitalia EuroCity, depart from Milano Centrale station.
Milan to Neu-Isenburg train services, operated by Trenitalia EuroCity, arrive at Frankfurt(Main)Hbf station.
The distance between Milan and Neu-Isenburg is 511.1 km. The road distance is 676 km.
Trenitalia EuroCity operates a train from Milano Centrale to Frankfurt(Main)Hbf twice daily. Tickets cost €130–200 and the journey takes 7h 34m.