The average train between Milan and Quartieri Spagnoli takes 7h 8m and the fastest train takes 5h 56m. The train service runs several times per day from Milan to Quartieri Spagnoli. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Milan and Quartieri Spagnoli. The earliest departure is at 4:40 AM at night, and the last departure from Milan is at 5:00 PM which arrives into Quartieri Spagnoli at 10:56 PM. All services require a transfer at Napoli Centrale and take an average of 7h 8m. The schedules shown below are for the next available departures.

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Want to know about travelling from Milan to Quartieri Spagnoli? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Milan to Quartieri Spagnoli. However, there are services departing from Milan station and arriving at Quartieri Spagnoli station via Napoli Centrale. The journey, including transfers, takes approximately 7h 8m.
Milan to Quartieri Spagnoli train services, operated by Trenitalia Frecce, depart from Milano Centrale station.
Milan to Quartieri Spagnoli train services, operated by Trenitalia Frecce, arrive at Napoli Centrale station.
The distance between Milan and Quartieri Spagnoli is 657.4 km. The road distance is 777 km.
Trenitalia Frecce operates a train from Milano Centrale to Napoli Centrale every 30 minutes. Tickets cost €110–230 and the journey takes 4h 38m. Two other operators also service this route.