The average train between Milan and Santa Maria delle Mole takes 4h 16m and the fastest train takes 3h 49m. There is a train service every few hours from Milan to Santa Maria delle Mole. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Milan and Santa Maria delle Mole. The earliest departure is at 5:10 AM in the morning, and the last departure from Milan is at 8:35 PM which arrives into Santa Maria delle Mole at 5:51 AM. All services require a transfer at Rome Termini and take an average of 4h 16m. The schedules shown below are for the next available departures.

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4h 16m • 1 changeWant to know about travelling from Milan to Santa Maria delle Mole? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Milan to Santa Maria delle Mole. However, there are services departing from Milano Centrale station and arriving at Roma Termini station via Roma Termini station. The journey, including transfers, takes approximately 4h 16m.
Milan to Santa Maria delle Mole train services, operated by ItaloTreno, depart from Milano Centrale station.
Milan to Santa Maria delle Mole train services, operated by ItaloTreno, arrive at Roma Termini station.
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The distance between Milan and Santa Maria delle Mole is 493.7 km. The road distance is 589 km.
ItaloTreno operates a train from Milano Centrale to Roma Termini every 30 minutes. Tickets cost €65–120 and the journey takes 3h 5m.