The average train between Milan and Santa Maria delle Mole takes 4h 34m and the fastest train takes 3h 49m. The train service runs several times per day from Milan to Santa Maria delle Mole. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Milan and Santa Maria delle Mole. The earliest departure is at 7:00 AM in the morning, and the last departure from Milan is at 8:35 PM which arrives into Santa Maria delle Mole at 5:51 AM. All services require a transfer, and take on average 4h 34m. The schedules shown below are for the next available departures.

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Want to know about travelling from Milan to Santa Maria delle Mole? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Milan to Santa Maria delle Mole. However, there are services departing from Milan station and arriving at Santa Maria delle Mole station via Roma Termini. The journey, including transfers, takes approximately 4h 34m.
Milan to Santa Maria delle Mole train services, operated by Trenitalia Frecce, depart from Milano Centrale station.
Milan to Santa Maria delle Mole train services, operated by Trenitalia Frecce, arrive at Roma Termini station.
Book your Milan to Santa Maria delle Mole train tickets online with Trenitalia Frecce, Trenitalia and ItaloTreno.
The distance between Milan and Santa Maria delle Mole is 493.7 km. The road distance is 579 km.
Trenitalia Frecce operates a train from Milano Centrale to Roma Termini every 20 minutes. Tickets cost €80–170 and the journey takes 3h 4m. ItaloTreno also services this route once daily.