The average train between Milan and Sestri Ponente takes 2h 10m and the fastest train takes 1h 51m. There is a train service every few hours from Milan to Sestri Ponente. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Milan and Sestri Ponente. The earliest departure is at 6:00 AM in the morning, and the last departure from Milan is at 10:05 PM which arrives into Sestri Ponente at 12:14 AM. All services require a transfer, and take on average 2h 10m. The schedules shown below are for the next available departures.

2h 6m • 1 change

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2h 16m • 1 change

2h 6m • 1 change

2h 5m • 1 change

2h 25m • 1 change

2h 16m • 1 change

2h 6m • 1 change

2h 5m • 1 change

2h 25m • 1 change

2h 16m • 1 change

2h 6m • 1 change
Want to know about travelling from Milan to Sestri Ponente? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Milan to Sestri Ponente. However, there are services departing from Milan station and arriving at Sestri Ponente station via Genova P.Za Principe. The journey, including transfers, takes approximately 2h 10m.
Milan to Sestri Ponente train services, operated by Trenitalia Intercity, depart from Milano Centrale station.
Milan to Sestri Ponente train services, operated by Trenitalia Intercity, arrive at Genova P.Za Principe station.
Book your Milan to Sestri Ponente train tickets online with Trenitalia Intercity, Trenitalia and Trenitalia Frecce.
The distance between Milan and Sestri Ponente is 118.6 km. The road distance is 145 km.
Trenitalia Intercity operates a train from Milano Centrale to Genova P.Za Principe hourly. Tickets cost €14–35 and the journey takes 1h 34m. Two other operators also service this route.