The average train between Milano Centrale Station and Mainz takes 9h 19m and the fastest train takes 8h 8m. The train service runs several times per day from Milano Centrale Station to Mainz. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Milano Centrale Station and Mainz. The earliest departure is at 7:10 AM in the morning, and the last departure from Milano Centrale Station is at 6:05 PM which arrives into Mainz at 5:38 AM. All services require a transfer at Basel SBB and take an average of 9h 19m. The schedules shown below are for the next available departures.


8h 8m • 2 changes


8h 8m • 2 changes


8h 43m • 2 changes
Arrives next day


11h 33m • 2 changes


8h 8m • 2 changes


8h 8m • 2 changes


8h 43m • 2 changes
Arrives next day


11h 33m • 2 changes


8h 8m • 2 changes


8h 8m • 2 changes


8h 43m • 2 changes
Arrives next day


11h 33m • 2 changes
Want to know about travelling from Milano Centrale Station to Mainz? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Milano Centrale Station to Mainz. However, there are services departing from Milano Centrale Station station and arriving at Mainz station via Basel Sbb. The journey, including transfers, takes approximately 9h 19m.
Milano Centrale Station to Mainz train services, operated by Trenitalia EuroCity, depart from Milano Centrale station.
Milano Centrale Station to Mainz train services, operated by Trenitalia EuroCity, arrive at Mainz, Hauptbahnhof station.
Book your Milano Centrale Station to Mainz train tickets online with Trenitalia EuroCity, Deutsche Bahn Intercity (DB IC) and Deutsche Bahn Regio (DB Regional).
The distance between Milano Centrale Station and Mainz is 504.8 km. The road distance is 685 km.
You can take a train from Milano Centrale to Mainz, Hauptbahnhof via Basel SBB and Mannheim, Hauptbahnhof in around 7h 45m.