The average train between Milano Centrale Station and Nyon takes 4h 25m and the fastest train takes 4h 12m. The train service runs several times per day from Milano Centrale Station to Nyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Milano Centrale Station and Nyon. The earliest departure is at 8:10 AM in the morning, and the last departure from Milano Centrale Station is at 7:10 PM which arrives into Nyon at 11:33 PM. All services require a transfer, and take on average 4h 25m. The schedules shown below are for the next available departures.

4h 12m • 1 change

4h 12m • 1 change
Arrives next day

5h 3m • 1 change

4h 12m • 1 change

4h 12m • 1 change
Arrives next day

5h 3m • 1 change

4h 12m • 1 change

4h 12m • 1 change
Arrives next day

5h 3m • 1 change

4h 12m • 1 change

4h 12m • 1 change
Arrives next day

5h 3m • 1 change
Want to know about travelling from Milano Centrale Station to Nyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Milano Centrale Station to Nyon. However, there are services departing from Milano Centrale Station station and arriving at Nyon station via Lausanne. The journey, including transfers, takes approximately 4h 25m.
Milano Centrale Station to Nyon train services, operated by Trenitalia EuroCity, depart from Milano Centrale station.
Milano Centrale Station to Nyon train services, operated by Trenitalia EuroCity, arrive at Lausanne station.
Book your Milano Centrale Station to Nyon train tickets online with Trenitalia EuroCity and Swiss Federal Railways (SBB CFF FFS).
The distance between Milano Centrale Station and Nyon is 249.9 km. The road distance is 342 km.
Trenitalia EuroCity operates a train from Milano Centrale to Lausanne every 4 hours. Tickets cost CHF 60–110 and the journey takes 3h 38m.