The average train between Milano Centrale Station and Roma Ostiense takes 3h 40m and the fastest train takes 3h 18m. There is a train service every few hours from Milano Centrale Station to Roma Ostiense. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Milano Centrale Station and Roma Ostiense. The earliest departure is at 6:15 AM in the morning, and the last departure from Milano Centrale Station is at 7:40 PM which arrives into Roma Ostiense at 11:35 PM. All services require a transfer at Roma Termini and take an average of 3h 40m. The schedules shown below are for the next available departures.

3h 52m • 1 change

3h 26m • 1 change

3h 55m • 1 change

3h 44m • 1 change

3h 50m • 1 change

3h 35m • 1 change

3h 38m • 1 change

3h 49m • 1 change

3h 50m • 1 change

3h 35m • 1 change

3h 38m • 1 change

3h 49m • 1 change

3h 50m • 1 change

3h 35m • 1 change

3h 38m • 1 change

3h 49m • 1 change
Want to know about travelling from Milano Centrale Station to Roma Ostiense? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Milano Centrale Station to Roma Ostiense. However, there are services departing from Milano Centrale Station station and arriving at Roma Ostiense station via Roma Termini. The journey, including transfers, takes approximately 3h 40m.
Milano Centrale Station to Roma Ostiense train services, operated by ItaloTreno, depart from Milano Centrale station.
Milano Centrale Station to Roma Ostiense train services, operated by ItaloTreno, arrive at Roma Termini station.
Book your Milano Centrale Station to Roma Ostiense train tickets online with ItaloTreno and ATAC S.p.A. Azienda per la mobilità.
The distance between Milano Centrale Station and Roma Ostiense is 480.6 km. The road distance is 585 km.
ItaloTreno operates a train from Milano Centrale to Roma Termini every 30 minutes. Tickets cost €75–150 and the journey takes 3h 5m.