The average train between Milton Keynes and Port of Holyhead takes 4h 18m and the fastest train takes 3h 26m. There is a train service every few hours from Milton Keynes to Port of Holyhead. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Milton Keynes and Port of Holyhead. The earliest departure is at 8:15 AM in the morning, and the last departure from Milton Keynes is at 10:41 PM which arrives into Port of Holyhead at 8:11 AM. All services require a transfer at Crewe and take an average of 4h 18m. The schedules shown below are for the next available departures.

3h 36m • 1 change

3h 57m • 1 change

3h 36m • 1 change

3h 48m • 1 change

3h 36m • 1 change

3h 57m • 1 change

3h 36m • 1 change

3h 48m • 1 change

3h 36m • 1 change

3h 57m • 1 change

3h 36m • 1 change

3h 48m • 1 change

3h 53m • 1 change

3h 37m • 1 change

3h 36m • 1 change

3h 56m • 1 change
Want to know about travelling from Milton Keynes to Port of Holyhead? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Milton Keynes to Port of Holyhead. However, there are services departing from Milton Keynes station and arriving at Port of Holyhead station via Crewe. The journey, including transfers, takes approximately 4h 18m.
Milton Keynes to Port of Holyhead train services, operated by Avanti West Coast, depart from Milton Keynes Central station.
Milton Keynes to Port of Holyhead train services, operated by Avanti West Coast, arrive at Holyhead station.
Book your Milton Keynes to Port of Holyhead train tickets online with Avanti West Coast, West Midlands Trains and Transport for Wales.
The distance between Milton Keynes and Port of Holyhead is 296.7 km. The road distance is 343 km.
You can take a train from Milton Keynes Central to Port of Holyhead via Crewe and Holyhead in around 4h 24m.