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Natick to Buffalo trains

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Trip Overview

The average train between Natick and Buffalo takes 27h 30m and the fastest train takes 27h 3m. The train runs, on average, 6 times per week from Natick to Buffalo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

27h 30m
Duration
479 mi
Distance
$340
Average price
6 times a week
Frequency

Natick to Buffalo train times

Trains run 6 times a week between Natick and Buffalo. The earliest departure is at 11:44 AM in the morning, and the last departure from Natick is at 12:29 PM which arrives into Buffalo at 3:40 PM. All services require a transfer at Framingham Amtrak and take an average of 27h 30m. The schedules shown below are for the next available departures.

Departing Friday, October 30, 2026

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    Arrives next day

    MBTAAmtrakAmtrak27h 11m • 2 changes

Departing Saturday, October 31, 2026

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    Arrives next day

    MBTAAmtrakAmtrak28h 56m • 2 changes

Departing Sunday, November 1, 2026

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    Arrives next day

    MBTAAmtrakAmtrak27h 48m • 2 changes

Departing Monday, November 2, 2026

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    Arrives next day

    MBTAAmtrakAmtrak27h 3m • 2 changes

Departing Tuesday, November 3, 2026

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    Arrives next day

    MBTAAmtrakAmtrak27h 3m • 2 changes

Departing Wednesday, November 4, 2026

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    Arrives next day

    MBTAAmtrakAmtrak27h 3m • 2 changes

Frequently asked questions

Want to know about travelling from Natick to Buffalo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Natick to Buffalo.ExpandLaunch map view
  • Distance: 478.7 mi
  • Duration: 27h 30m

What companies run services between Natick, MA, USA and Buffalo, NY, USA?

Amtrak operates a train from Framingham Amtrak to Buffalo Depew Station once daily. Tickets cost $250–400 and the journey takes 11h 4m.

Operators