The average train between Neu-Isenburg and Berlin takes 4h 37m and the fastest train takes 4h 8m. There is an hourly train service from Neu-Isenburg to Berlin. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Neu-Isenburg and Berlin. The earliest departure is at 1:41 AM at night, and the last departure from Neu-Isenburg is at 11:05 PM which arrives into Berlin at 5:56 AM. All services require a transfer at Frankfurt, Hauptbahnhof FOB and take an average of 4h 37m. The schedules shown below are for the next available departures.

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4h 43m • 1 changeWant to know about travelling from Neu-Isenburg to Berlin? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Neu-Isenburg to Berlin. However, there are services departing from Frankfurt station and arriving at Berlin Hbf station via Berlin Hbf station. The journey, including transfers, takes approximately 4h 37m.
Neu-Isenburg to Berlin train services, operated by Deutsche Bahn Intercity (DB IC), depart from Frankfurt station.
Neu-Isenburg to Berlin train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Berlin Hbf station.
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The distance between Neu-Isenburg and Berlin is 428.1 km. The road distance is 520 km.
Deutsche Bahn Intercity (DB IC) operates a train from Frankfurt to Berlin Hbf hourly. Tickets cost €85–190 and the journey takes 4h 2m.