The average train between Neu-Isenburg and Karlsruhe takes 1h 35m and the fastest train takes 1h 23m. There is a train service every few hours from Neu-Isenburg to Karlsruhe. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Neu-Isenburg and Karlsruhe. The earliest departure is at 8:30 AM in the morning, and the last departure from Neu-Isenburg is at 10:20 PM which arrives into Karlsruhe at 11:59 PM. All services require a transfer at Frankfurt, Hauptbahnhof FOB and take an average of 1h 35m. The schedules shown below are for the next available departures.

1h 28m • 1 change

1h 59m • 1 change

1h 23m • 1 change

1h 29m • 1 change

1h 29m • 1 change

1h 59m • 1 change

1h 23m • 1 change

1h 29m • 1 change

1h 29m • 1 change

1h 59m • 1 change

1h 23m • 1 change

1h 29m • 1 change

1h 29m • 1 change

1h 59m • 1 change

1h 23m • 1 change

1h 29m • 1 change
Want to know about travelling from Neu-Isenburg to Karlsruhe? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Neu-Isenburg to Karlsruhe. However, there are services departing from Neu-Isenburg station and arriving at Karlsruhe station via Karlsruhe Hauptbahnhof. The journey, including transfers, takes approximately 1h 35m.
Neu-Isenburg to Karlsruhe train services, operated by Verkehrsgesellschaft Frankfurt (VGF-FFM), depart from Frankfurt station.
Neu-Isenburg to Karlsruhe train services, operated by Verkehrsgesellschaft Frankfurt (VGF-FFM), arrive at Karlsruhe Hauptbahnhof station.
Book your Neu-Isenburg to Karlsruhe train tickets online with Verkehrsgesellschaft Frankfurt (VGF-FFM) and Deutsche Bahn Intercity (DB IC).
The distance between Neu-Isenburg and Karlsruhe is 117.4 km. The road distance is 144 km.
Deutsche Bahn Intercity (DB IC) operates a train from Frankfurt to Karlsruhe Hauptbahnhof hourly. Tickets cost €25–110 and the journey takes 1h 9m. Österreichische Bundesbahnen also services this route twice a week.