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Neu-Isenburg to Karlsruhe trains

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Trip Overview

The average train between Neu-Isenburg and Karlsruhe takes 1h 29m and the fastest train takes 1h 23m. There is a train service every few hours from Neu-Isenburg to Karlsruhe. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

1h 29m
Duration
144 km
Distance
€33
Average price
Hourly
Frequency

Train

best
  1. Take the train from Frankfurt to Karlsruhe Hauptbahnhoftrain train 12 / ...
1h 49m
€26–53

Neu-Isenburg to Karlsruhe train times

Trains run hourly between Neu-Isenburg and Karlsruhe. The earliest departure is at 5:20 AM in the morning, and the last departure from Neu-Isenburg is at 10:20 PM which arrives into Karlsruhe at 11:59 PM. All services require a transfer at Frankfurt, Hauptbahnhof FOB and take an average of 1h 29m. The schedules shown below are for the next available departures.

Departing Saturday, October 10, 2026

  •  → 

    Verkehrsgesellschaft Frankfurt (VGF-FFM)Deutsche Bahn Intercity (DB IC)1h 33m • 1 change

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    Verkehrsgesellschaft Frankfurt (VGF-FFM)Deutsche Bahn Intercity (DB IC)1h 39m • 1 change

Departing Sunday, October 11, 2026

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    Verkehrsgesellschaft Frankfurt (VGF-FFM)Deutsche Bahn Intercity (DB IC)1h 34m • 1 change

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    Verkehrsgesellschaft Frankfurt (VGF-FFM)Deutsche Bahn Intercity (DB IC)1h 53m • 1 change

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    Verkehrsgesellschaft Frankfurt (VGF-FFM)Deutsche Bahn Intercity (DB IC)1h 49m • 1 change

  •  → 

    Verkehrsgesellschaft Frankfurt (VGF-FFM)Deutsche Bahn Intercity (DB IC)1h 34m • 1 change
  • Show more

Departing Monday, October 12, 2026

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    Verkehrsgesellschaft Frankfurt (VGF-FFM)Deutsche Bahn Intercity (DB IC)1h 39m • 1 change

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    Verkehrsgesellschaft Frankfurt (VGF-FFM)Deutsche Bahn Intercity (DB IC)1h 29m • 1 change

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    Verkehrsgesellschaft Frankfurt (VGF-FFM)Deutsche Bahn Intercity (DB IC)1h 29m • 1 change

  •  → 

    Verkehrsgesellschaft Frankfurt (VGF-FFM)Deutsche Bahn Intercity (DB IC)1h 29m • 1 change
  • Show more

Departing Tuesday, October 13, 2026

  •  → 

    Verkehrsgesellschaft Frankfurt (VGF-FFM)Deutsche Bahn Intercity (DB IC)1h 39m • 1 change

  •  → 

    Verkehrsgesellschaft Frankfurt (VGF-FFM)Deutsche Bahn Intercity (DB IC)1h 29m • 1 change

  •  → 

    Verkehrsgesellschaft Frankfurt (VGF-FFM)Deutsche Bahn Intercity (DB IC)1h 29m • 1 change

  •  → 

    Verkehrsgesellschaft Frankfurt (VGF-FFM)Deutsche Bahn Intercity (DB IC)1h 29m • 1 change
  • Show more

Frequently asked questions

Want to know about travelling from Neu-Isenburg to Karlsruhe? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Neu-Isenburg to Karlsruhe.ExpandLaunch map view
  • Distance: 144 km
  • Duration: 1h 29m

What companies run services between Neu-Isenburg, Germany and Karlsruhe, Germany?

Deutsche Bahn Intercity (DB IC) operates a train from Frankfurt to Karlsruhe Hauptbahnhof hourly. Tickets cost €25–50 and the journey takes 1h 8m. Süwex also services this route 3 times a day.

Operators