The average train between Neuss and Karlsruhe takes 3h 9m and the fastest train takes 3h 7m. The train service runs several times per day from Neuss to Karlsruhe. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Neuss and Karlsruhe. The earliest departure is at 3:23 AM at night, and the last departure from Neuss is at 7:52 PM which arrives into Karlsruhe at 10:59 PM. All services require a transfer, and take on average 3h 9m. The schedules shown below are for the next available departures.

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3h 7m • 1 changeWant to know about travelling from Neuss to Karlsruhe? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Neuss to Karlsruhe. However, there are services departing from Köln Hbf station and arriving at Karlsruhe Hauptbahnhof station via Karlsruhe Hauptbahnhof station. The journey, including transfers, takes approximately 3h 9m.
Neuss to Karlsruhe train services, operated by Deutsche Bahn Intercity (DB IC), depart from Köln Hbf station.
Neuss to Karlsruhe train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Karlsruhe Hauptbahnhof station.
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The distance between Neuss and Karlsruhe is 272.5 km. The road distance is 337 km.
Deutsche Bahn Intercity (DB IC) operates a train from Köln Hbf to Karlsruhe Hauptbahnhof hourly. Tickets cost €50–110 and the journey takes 2h 5m.